021-51111890
购物车（）
sales@molnova.cn
首页-
Products -
Endocrinology/Hormones -
5-HT Receptor -
NLX-204 hydrochloride（2170405-10-2 free base）
NLX-204 hydrochloride（2170405-10-2 free base）
CAS No. ——
NLX-204 hydrochloride（2170405-10-2 free base） ( —— )
产品货号. M22899 CAS No. ——
NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1970 | 有现货 |
|
| 10MG | ￥3290 | 有现货 |
|
| 25MG | ￥4638 | 有现货 |
|
| 50MG | ￥6756 | 有现货 |
|
| 100MG | 获取报价 | 有现货 |
|
| 200MG | 获取报价 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
-
产品名称NLX-204 hydrochloride（2170405-10-2 free base）
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.
-
产品描述NLX-204 hydrochloride is a potent and selective ERK1/2 phosphorylation-preferring serotonin 5 HT1A receptor agonist(pKi = 10.19).NLX-204, displayed high selectivity in the SafetyScreen44 panel (including hERG channel), high solubility, metabolic stability, and Caco-2 penetration and did not block CYP3A4, CYP2D6 isoenzymes, or P-glycoprotein.Preliminary in vivo studies confirmed its promising pharmacokinetic profile.NLX-204 also robustly stimulated ERK1/2 phosphorylation in rat cortex and showed highly potent (MED = 0.16 mg/kg) and efficacious antidepressant-like activity, totally eliminating immobility in the rat Porsolt test.
-
同义词——
-
通路Endocrinology/Hormones
-
靶点5-HT Receptor
-
受体5-HT1A
-
研究领域——
-
适应症——
化学信息
-
CAS Number——
-
分子量409.13
-
分子式C20H23Cl2F2N3O2
-
纯度>98% (HPLC)
-
溶解度——
-
SMILES[H]Cl.O=C(C1=CC=C(F)C(Cl)=C1)N2CCC(CNCCOC3=NC=CC=C3)(F)CC2
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Sniecikowska, Joanna, Guch-Lutwin, Monika, Bucki, Adam,et al. Novel aryloxyethyl derivatives of 1-(1-benzoylpiperidin-4-yl)methanamine as the Extracellular Regulated Kinases 1/2 (ERK1/2) phosphorylation-preferring serotonin 5 HT1A receptor biased agonists with robust antidepressant-like activity[J]. Journal of Medicinal Chemistry, 2019.
产品手册
关联产品
-
RS 127445
RS 127445 is a selective high affinity orally bioavailable 5-HT2B receptor antagonist(pKi : 9.5).
-
Dihydroergotamine Me...
Dihydroergotamine mesylate is an ergot alkaloid used to treat migraines.
-
p-MPPI hydrochloride
p-MPPI hydrochloride is a selective antagonist of 5-HT1A receptor, and has antidepressant and anxiolytic-like effects.
